A Signal-Language Foundation Model for Broad-Spectrum Cardiovascular Assessment from Routine Electrocardiography

Electrocardiography (ECG) is central to cardiovascular care, but conventional AI models are often restricted to common arrhythmias and may generalize poorly across populations or clinically subtle diseases. We developed ECG Contrastive Language-Image Pre-training (ECGCLIP), a signal-language contrastive learning framework that aligns ECG waveforms with expert diagnostic reports. ECGCLIP was pre-trained on 2,837,962 ECG studies from 1,324,856 patients and evaluated on a held-out internal test set plus nine independent external cohorts comprising about 1.5 million ECGs. Evaluation covered 89 downstream tasks, including 45 ECG diagnoses, 39 echocardiographic targets, and 5 rare cardiac diseases, using PRAUC as the primary metric. ECGCLIP consistently improved performance over random initialization and Merl-R18 baselines. On the internal test set, ECGCLIP-R34 achieved strong performance for atrial fibrillation (PRAUC 0.900) and ST-segment elevation myocardial infarction (PRAUC 0.383), with robust generalization across all external cohorts. It also improved low-prevalence and diagnostically elusive diseases, including Ebstein anomaly, constrictive pericarditis, dextrocardia, and cardiac amyloidosis, with internal PRAUC values of 0.253, 0.175, 0.121, and 0.201, respectively. ECGCLIP was data efficient, matching or exceeding full-dataset baseline performance with only 10% of training data. Feature visualization and saliency analysis suggested clinically meaningful representations aligned with established electrocardiographic criteria. These findings indicate that large-scale ECG-report contrastive pre-training can expand routine ECG interpretation beyond common arrhythmias toward broad cardiovascular assessment and opportunistic screening of echocardiographic and rare conditions.

PersonaGesture: Single-Reference Co-Speech Gesture Personalization for Unseen Speakers

We propose PersonaGesture, a diffusion-based pipeline for single-reference co-speech gesture personalization of unseen speakers. Given target speech and one motion clip from a new speaker, the model must synthesize gestures that follow the new utterance while retaining speaker-specific pose choices, without per-speaker optimization. This setting is useful for avatars and virtual agents, but it is hard because the reference mixes stable speaker habits with utterance-specific trajectories. PersonaGesture consists of two key components, Adaptive Style Infusion (ASI) and Implicit Distribution Rectification (IDR), to separate temporal identity evidence from residual statistic correction. A Style Perceiver first encodes the variable-length reference into compact speaker-memory tokens. ASI injects these tokens into denoising through zero-initialized residual cross-attention, enabling style evidence to affect motion formation without replacing the pretrained speech-to-motion prior. Building on this, IDR applies a length-aware diagonal affine map in latent space to correct residual channel-wise moments estimated from the same reference. Across BEAT2 and ZeroEGGS, we evaluate quantitative metrics, reference-identity controls, same-audio diagnostics, qualitative comparisons, and human preference. Experiments show that separating denoising-time speaker memory from conservative post-generation moment correction improves unseen-speaker personalization over collapsed style codes, full-reference attention, and one-clip finetuning. Project: https://xiangyue-zhang.github.io/PersonaGesture.

Think and Answer ME: Benchmarking and Exploring Multi-Entity Reasoning Grounding in Remote Sensing

Recent advances in reasoning language models and reinforcement learning with verifiable rewards have significantly enhanced multi-step reasoning capabilities. This progress motivates the extension of reasoning paradigms to remote sensing visual grounding task. However, existing remote sensing grounding methods remain largely confined to perception-level matching and single-entity formulations, limiting the role of explicit reasoning and inter-entity modeling. To address this challenge, we introduce a new benchmark dataset for Multi-Entity Reasoning Grounding in Remote Sensing (ME-RSRG). Based on ME-RSRG, we reformulate remote sensing grounding as a multi-entity reasoning task and propose an Entity-Aware Reasoning (EAR) framework built upon visual-linguistic foundation models. EAR generates structured reasoning traces and subject-object grounding outputs. It adopts supervised fine-tuning for cold-start initialization and is further optimized via entity-aware reward-driven Group Relative Policy Optimization (GRPO). Extensive experiments on ME-RSRG demonstrate the challenges of multi-entity reasoning and verify the effectiveness of our proposed EAR framework. Our dataset, code, and models will be available at https://github.com/CV-ShuchangLyu/ME-RSRG.

Learning Memory-Enhanced Improvement Heuristics for Flexible Job Shop Scheduling

The rise of smart manufacturing under Industry 4.0 introduces mass customization and dynamic production, demanding more advanced and flexible scheduling techniques. The flexible job-shop scheduling problem (FJSP) has attracted significant attention due to its complex constraints and strong alignment with real-world production scenarios. Current deep reinforcement learning (DRL)-based approaches to FJSP predominantly employ constructive methods. While effective, they often fall short of reaching (near-)optimal solutions. In contrast, improvement-based methods iteratively explore the neighborhood of initial solutions and are more effective in approaching optimality. However, the flexible machine allocation in FJSP poses significant challenges to the application of this framework, including accurate state representation, effective policy learning, and efficient search strategies. To address these challenges, this paper proposes a Memory-enhanced Improvement Search framework with heterogeneous graph representation--MIStar. It employs a novel heterogeneous disjunctive graph that explicitly models the operation sequences on machines to accurately represent scheduling solutions. Moreover, a memoryenhanced heterogeneous graph neural network (MHGNN) is designed for feature extraction, leveraging historical trajectories to enhance the decision-making capability of the policy network. Finally, a parallel greedy search strategy is adopted to explore the solution space, enabling superior solutions with fewer iterations. Extensive experiments on synthetic data and public benchmarks demonstrate that MIStar significantly outperforms both traditional handcrafted improvement heuristics and state-of-the-art DRL-based constructive methods.

Trajectory Generation with Endpoint Regulation and Momentum-Aware Dynamics for Visually Impaired Scenarios

Trajectory generation for visually impaired scenarios requires smooth and temporally consistent state in structured, low-speed dynamic environments. However, traditional jerk-based heuristic trajectory sampling with independent segment generation and conventional smoothness penalties often lead to unstable terminal behavior and state discontinuities under frequent regenerating. This paper proposes a trajectory generation approach that integrates endpoint regulation to stabilize terminal states within each segment and momentum-aware dynamics to regularize the evolution of velocity and acceleration for segment consistency. Endpoint regulation is incorporated into trajectory sampling to stabilize terminal behavior, while a momentum-aware dynamics enforces consistent velocity and acceleration evolution across consecutive trajectory segments. Experimental results demonstrate reduced acceleration peaks and lower jerk levels with decreased dispersion, smoother velocity and acceleration profiles, more stable endpoint distributions, and fewer infeasible trajectory candidates compared with a baseline planner.

Towards Interactive Intelligence for Digital Humans

We introduce Interactive Intelligence, a novel paradigm of digital human that is capable of personality-aligned expression, adaptive interaction, and self-evolution. To realize this, we present Mio (Multimodal Interactive Omni-Avatar), an end-to-end framework composed of five specialized modules: Thinker, Talker, Face Animator, Body Animator, and Renderer. This unified architecture integrates cognitive reasoning with real-time multimodal embodiment to enable fluid, consistent interaction. Furthermore, we establish a new benchmark to rigorously evaluate the capabilities of interactive intelligence. Extensive experiments demonstrate that our framework achieves superior performance compared to state-of-the-art methods across all evaluated dimensions. Together, these contributions move digital humans beyond superficial imitation toward intelligent interaction.

TCIP: Threshold-Controlled Iterative Pyramid Network for Deformable Medical Image Registration

Although pyramid networks have demonstrated superior performance in deformable medical image registration, their decoder architectures are inherently prone to propagating and accumulating anatomical structure misalignments. Moreover, most existing models do not adaptively determine the number of iterations for optimization under varying deformation requirements across images, resulting in either premature termination or excessive iterations that degrades registration accuracy. To effectively mitigate the accumulation of anatomical misalignments, we propose the Feature-Enhanced Residual Module (FERM) as the core component of each decoding layer in the pyramid network. FERM comprises three sequential blocks that extract anatomical semantic features, learn to suppress irrelevant features, and estimate the final deformation field, respectively. To adaptively determine the number of iterations for varying images, we propose the dual-stage Threshold-Controlled Iterative (TCI) strategy. In the first stage, TCI assesses registration stability and with asserted stability, it continues with the second stage to evaluate convergence. We coin the model that integrates FERM and TCI as Threshold-Controlled Iterative Pyramid (TCIP). Extensive experiments on three public brain MRI datasets and one abdomen CT dataset demonstrate that TCIP outperforms the state-of-the-art (SOTA) registration networks in terms of accuracy, while maintaining comparable inference speed and a compact model parameter size. Finally, we assess the generalizability of FERM and TCI by integrating them with existing registration networks and further conduct ablation studies to validate the effectiveness of these two proposed methods.

Momentum-constrained Hybrid Heuristic Trajectory Optimization Framework with Residual-enhanced DRL for Visually Impaired Scenarios

This paper proposes a momentum-constrained hybrid heuristic trajectory optimization framework (MHHTOF) tailored for assistive navigation in visually impaired scenarios, integrating trajectory sampling generation, optimization and evaluation with residual-enhanced deep reinforcement learning (DRL). In the first stage, heuristic trajectory sampling cluster (HTSC) is generated in the Frenet coordinate system using third-order interpolation with fifth-order polynomials and momentum-constrained trajectory optimization (MTO) constraints to ensure smoothness and feasibility. After first stage cost evaluation, the second stage leverages a residual-enhanced actor-critic network with LSTM-based temporal feature modeling to adaptively refine trajectory selection in the Cartesian coordinate system. A dual-stage cost modeling mechanism (DCMM) with weight transfer aligns semantic priorities across stages, supporting human-centered optimization. Experimental results demonstrate that the proposed LSTM-ResB-PPO achieves significantly faster convergence, attaining stable policy performance in approximately half the training iterations required by the PPO baseline, while simultaneously enhancing both reward outcomes and training stability. Compared to baseline method, the selected model reduces average cost and cost variance by 30.3% and 53.3%, and lowers ego and obstacle risks by over 77%. These findings validate the framework's effectiveness in enhancing robustness, safety, and real-time feasibility in complex assistive planning tasks.

GELD: A Unified Neural Model for Efficiently Solving Traveling Salesman Problems Across Different Scales

The Traveling Salesman Problem (TSP) is a well-known combinatorial optimization problem with broad real-world applications. Recent advancements in neural network-based TSP solvers have shown promising results. Nonetheless, these models often struggle to efficiently solve both small- and large-scale TSPs using the same set of pre-trained model parameters, limiting their practical utility. To address this issue, we introduce a novel neural TSP solver named GELD, built upon our proposed broad global assessment and refined local selection framework. Specifically, GELD integrates a lightweight Global-view Encoder (GE) with a heavyweight Local-view Decoder (LD) to enrich embedding representation while accelerating the decision-making process. Moreover, GE incorporates a novel low-complexity attention mechanism, allowing GELD to achieve low inference latency and scalability to larger-scale TSPs. Additionally, we propose a two-stage training strategy that utilizes training instances of different sizes to bolster GELD's generalization ability. Extensive experiments conducted on both synthetic and real-world datasets demonstrate that GELD outperforms seven state-of-the-art models considering both solution quality and inference speed. Furthermore, GELD can be employed as a post-processing method to significantly elevate the quality of the solutions derived by existing neural TSP solvers via spending affordable additional computing time. Notably, GELD is shown as capable of solving TSPs with up to 744,710 nodes, first-of-its-kind to solve this large size TSP without relying on divide-and-conquer strategies to the best of our knowledge.

UniPTMs: The First Unified Multi-type PTM Site Prediction Model via Master-Slave Architecture-Based Multi-Stage Fusion Strategy and Hierarchical Contrastive Loss

As a core mechanism of epigenetic regulation in eukaryotes, protein post-translational modifications (PTMs) require precise prediction to decipher dynamic life activity networks. To address the limitations of existing deep learning models in cross-modal feature fusion, domain generalization, and architectural optimization, this study proposes UniPTMs: the first unified framework for multi-type PTM prediction. The framework innovatively establishes a "Master-Slave" dual-path collaborative architecture: The master path dynamically integrates high-dimensional representations of protein sequences, structures, and evolutionary information through a Bidirectional Gated Cross-Attention (BGCA) module, while the slave path optimizes feature discrepancies and recalibration between structural and traditional features using a Low-Dimensional Fusion Network (LDFN). Complemented by a Multi-scale Adaptive convolutional Pyramid (MACP) for capturing local feature patterns and a Bidirectional Hierarchical Gated Fusion Network (BHGFN) enabling multi-level feature integration across paths, the framework employs a Hierarchical Dynamic Weighting Fusion (HDWF) mechanism to intelligently aggregate multimodal features. Enhanced by a novel Hierarchical Contrastive loss function for feature consistency optimization, UniPTMs demonstrates significant performance improvements (3.2%-11.4% MCC and 4.2%-14.3% AP increases) over state-of-the-art models across five modification types and transcends the Single-Type Prediction Paradigm. To strike a balance between model complexity and performance, we have also developed a lightweight variant named UniPTMs-mini.